The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolut...
The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution
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United States: Public Library of Science
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Language
English
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United States: Public Library of Science
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Bemnifosbuvir (AT-527) and AT-752 are guanosine analogues currently in clinical trials against several RNA viruses. Here, we show that these drugs require a minimal set of 5 cellular enzymes for activation to their common 5'-triphosphate AT-9010, with an obligate order of reactions. AT-9010 selectively inhibits essential viral enzymes, accounting f...
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Full title
The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution
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TN_cdi_doaj_primary_oai_doaj_org_article_1f28c80a6c2249f99b5ce2dcf371e76b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f28c80a6c2249f99b5ce2dcf371e76b
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ISSN
1545-7885,1544-9173
E-ISSN
1545-7885
DOI
10.1371/journal.pbio.3002743
