Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Activation of microglia is a prominent pathological feature in tauopathies, including Alzheimer’s disease. How microglia activation contributes to tau toxicity remains largely unknown. Here we show that nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling, activated by tau, drives microglial-mediated tau propagation and...
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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy
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TN_cdi_doaj_primary_oai_doaj_org_article_1f855da0da7c4c2995106bb45af63b8f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f855da0da7c4c2995106bb45af63b8f
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29552-6
