G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
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Author / Creator
Simone, Roberto , Balendra, Rubika , Moens, Thomas G , Preza, Elisavet , Wilson, Katherine M , Heslegrave, Amanda , Woodling, Nathan S , Niccoli, Teresa , Gilbert‐Jaramillo, Javier , Abdelkarim, Samir , Clayton, Emma L , Clarke, Mica , Konrad, Marie‐Therese , Nicoll, Andrew J , Mitchell, Jamie S , Calvo, Andrea , Chio, Adriano , Houlden, Henry , Polke, James M , Ismail, Mohamed A , Stephens, Chad E , Vo, Tam , Farahat, Abdelbasset A , Wilson, W David , Boykin, David W , Zetterberg, Henrik , Partridge, Linda , Wray, Selina , Parkinson, Gary , Neidle, Stephen , Patani, Rickie , Fratta, Pietro and Isaacs, Adrian M
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Intronic GGGGCC repeat expansions in
C9orf72
are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. Repeat expansions have been proposed to cause disease by both the repeat RNA forming foci that sequester RNA...
Alternative Titles
Full title
G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
Authors, Artists and Contributors
Author / Creator
Balendra, Rubika
Moens, Thomas G
Preza, Elisavet
Wilson, Katherine M
Heslegrave, Amanda
Woodling, Nathan S
Niccoli, Teresa
Gilbert‐Jaramillo, Javier
Abdelkarim, Samir
Clayton, Emma L
Clarke, Mica
Konrad, Marie‐Therese
Nicoll, Andrew J
Mitchell, Jamie S
Calvo, Andrea
Chio, Adriano
Houlden, Henry
Polke, James M
Ismail, Mohamed A
Stephens, Chad E
Vo, Tam
Farahat, Abdelbasset A
Wilson, W David
Boykin, David W
Zetterberg, Henrik
Partridge, Linda
Wray, Selina
Parkinson, Gary
Neidle, Stephen
Patani, Rickie
Fratta, Pietro
Isaacs, Adrian M
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Primary Identifiers
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TN_cdi_doaj_primary_oai_doaj_org_article_1f8b61ee6cea4757929c90eeb5c2d015
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1f8b61ee6cea4757929c90eeb5c2d015
Other Identifiers
ISSN
1757-4676
E-ISSN
1757-4684
DOI
10.15252/emmm.201707850
