Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Neurokinin 1 receptor (NK1R) has key regulating functions in the central and peripheral nervous systems, and NK1R antagonists such as aprepitant have been approved for treating chemotherapy-induced nausea and vomiting. However, the lack of data on NK1R structure and biochemistry has limited further drug development targeting this receptor. Here, we...
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Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
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TN_cdi_doaj_primary_oai_doaj_org_article_1fea1939297743138267a644666827c0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_1fea1939297743138267a644666827c0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-08568-5
