Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and countera...
Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Contents
Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion gene resulting from the t(9;22)(q34;q11) chromosomal translocation, is thought to be the driver event responsible for initiation and maintenance of chronic myeloid leukemia (CML). BCR-ABL1 was one of the first tyrosine kinases to be implicated in a human malignanc...
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Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_20b226ea95774f068eed7f00d2a46eaf
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_20b226ea95774f068eed7f00d2a46eaf
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ISSN
1476-4598
E-ISSN
1476-4598
DOI
10.1186/s12943-018-0780-6
