Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug dispositi...
Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model
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United States: John Wiley & Sons, Inc
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Language
English
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Publisher
United States: John Wiley & Sons, Inc
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Telmisartan, a selective inhibitor of angiotensin II receptor type 1 (AT1), demonstrates nonlinear pharmacokinetics (PK) when orally administered in ascending doses to healthy volunteers, but the underlying mechanisms remain unclear. This study presents a physiologically based pharmacokinetic model integrated with target‐mediated drug disposition (...
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Full title
Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model
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TN_cdi_doaj_primary_oai_doaj_org_article_20fce9b65c2545e7ac580a6c2b9469b0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_20fce9b65c2545e7ac580a6c2b9469b0
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ISSN
2163-8306
E-ISSN
2163-8306
DOI
10.1002/psp4.13154
