Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
About this item
Full title
Author / Creator
Lee, Eric Hee Jun , Murad, John P. , Christian, Lea , Gibson, Jackson , Yamaguchi, Yukiko , Cullen, Cody , Gumber, Diana , Park, Anthony K. , Young, Cari , Monroy, Isabel , Yang, Jason , Stern, Lawrence A. , Adkins, Lauren N. , Dhapola, Gaurav , Gittins, Brenna , Chang, Wen-Chung , Martinez, Catalina , Woo, Yanghee , Cristea, Mihaela , Rodriguez-Rodriguez, Lorna , Ishihara, Jun , Lee, John K. , Forman, Stephen J. , Wang, Leo D. and Priceman, Saul J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Chimeric antigen receptor (CAR) T cell therapeutic responses are hampered by limited T cell trafficking, persistence, and durable anti-tumor activity in solid tumors. However, these challenges can be largely overcome by relatively unconstrained synthetic engineering strategies. Here, we describe CAR T cells targeting tumor-associated glycoprotein-7...
Alternative Titles
Full title
Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting
Authors, Artists and Contributors
Author / Creator
Murad, John P.
Christian, Lea
Gibson, Jackson
Yamaguchi, Yukiko
Cullen, Cody
Gumber, Diana
Park, Anthony K.
Young, Cari
Monroy, Isabel
Yang, Jason
Stern, Lawrence A.
Adkins, Lauren N.
Dhapola, Gaurav
Gittins, Brenna
Chang, Wen-Chung
Martinez, Catalina
Woo, Yanghee
Cristea, Mihaela
Rodriguez-Rodriguez, Lorna
Ishihara, Jun
Lee, John K.
Forman, Stephen J.
Wang, Leo D.
Priceman, Saul J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_211ce127e82c40c7b1c8f149a15dcd09
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_211ce127e82c40c7b1c8f149a15dcd09
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40115-1
