Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation...
Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Tau tubulin kinase-1 (TTBK1), a neuron-specific tau kinase, is highly expressed in the entorhinal cortex and hippocampal regions, where early tau pathology evolves in Alzheimer's disease (AD). The protein expression level of TTBK1 is elevated in the cortex brain tissues with AD patients compared to the control subjects. We therefore hypothesized th...
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Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice
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TN_cdi_doaj_primary_oai_doaj_org_article_211e531676fe4141a9564a629434326f
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_211e531676fe4141a9564a629434326f
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ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-023-01661-3
