Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Mutations in E3 ubiquitin ligase Parkin have been linked to familial Parkinson’s disease. Accumulating evidence suggests that Parkin is a tumor suppressor, but the underlying mechanism is poorly understood. Here we show that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1α (HIF-1α). Parkin interacts with HIF-1α and promotes HIF-1α d...
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Full title
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression
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TN_cdi_doaj_primary_oai_doaj_org_article_21615c60190c416990f49adb86754ecf
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_21615c60190c416990f49adb86754ecf
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-01947-w
