Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalon...
Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency
About this item
Full title
Author / Creator
Munoz, Marcia A. , Skinner, Oliver P. , Masle-Farquhar, Etienne , Jurczyluk, Julie , Xiao, Ya , Fletcher, Emma K. , Kristianto, Esther , Hodson, Mark P. , O’Donoghue, Seán I. , Kaur, Sandeep , Brink, Robert , Zahra, David G. , Deenick, Elissa K. , Perry, Kristen A. , Robertson, Avril A.B. , Mehr, Sam , Hissaria, Pravin , Mulders-Manders, Catharina M. , Simon, Anna and Rogers, Michael J.
Publisher
Ann Arbor: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
Ann Arbor: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Mevalonate kinase deficiency (MKD) is characterized by recurrent fevers and flares of systemic inflammation, caused by biallelic loss-of-function mutations in MVK. The underlying disease mechanisms and triggers of inflammatory flares are poorly understood because of the lack of in vivo models. We describe genetically modified mice bearing the hypom...
Alternative Titles
Full title
Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency
Authors, Artists and Contributors
Author / Creator
Skinner, Oliver P.
Masle-Farquhar, Etienne
Jurczyluk, Julie
Xiao, Ya
Fletcher, Emma K.
Kristianto, Esther
Hodson, Mark P.
O’Donoghue, Seán I.
Kaur, Sandeep
Brink, Robert
Zahra, David G.
Deenick, Elissa K.
Perry, Kristen A.
Robertson, Avril A.B.
Mehr, Sam
Hissaria, Pravin
Mulders-Manders, Catharina M.
Simon, Anna
Rogers, Michael J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_21b5b88799f3482d9c5c720c2d6c2ea8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_21b5b88799f3482d9c5c720c2d6c2ea8
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI160929
