Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo
Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Biliverdin IXβ reductase (BLVRB) is an NADPH-dependent enzyme previously implicated in a redox-regulated mechanism of thrombopoiesis distinct from the thrombopoietin (TPO)/c-MPL axis. Here, we apply computational modeling to inform molecule design, followed by de novo syntheses and screening of unique small molecules retaining the capacity for sele...
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Small molecule BLVRB redox inhibitor promotes megakaryocytopoiesis and stress thrombopoiesis in vivo
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TN_cdi_doaj_primary_oai_doaj_org_article_21e4f570c1604513949f47f5d470c3c6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_21e4f570c1604513949f47f5d470c3c6
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58497-9
