Sulfoxide‐Mediated Cys‐Trp‐Selective Bioconjugation that Enables Protein Labeling and Peptide Hetero...
Sulfoxide‐Mediated Cys‐Trp‐Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization
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Author / Creator
Kobayashi, Daishiro , Denda, Masaya , Hayashi, Junya , Hidaka, Kota , Kohmura, Yutaka , Tsunematsu, Takaaki , Nishino, Kohei , Yoshikawa, Harunori , Ohkawachi, Kento , Nigorikawa, Kiyomi , Yoshimaru, Tetsuro , Ishimaru, Naozumi , Nomura, Wataru , Katagiri, Toyomasa , Kosako, Hidetaka and Otaka, Akira
Publisher
Wiley-VCH
Journal title
Language
English
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Publisher
Wiley-VCH
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Scope and Contents
Contents
A method was developed that enables the magnesium chloride (MgCl2)‐activated S‐acetamidomethyl cysteine sulfoxide (Cys(Acm)(O)) to induce the sp2(C−H) sulfenylation of the indole of Trp residues. The reaction operates under mild acidic conditions using acetic acid or an ionic liquid to give the Trp‐sulfenylated products. Other than Trp, all other p...
Alternative Titles
Full title
Sulfoxide‐Mediated Cys‐Trp‐Selective Bioconjugation that Enables Protein Labeling and Peptide Heterodimerization
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_222723dbb8234764ba71bc9a59b8809f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_222723dbb8234764ba71bc9a59b8809f
Other Identifiers
ISSN
2751-4765
E-ISSN
2751-4765
DOI
10.1002/ceur.202400014
