miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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In type 1 diabetes, the appearance of islet autoantibodies indicates the onset of islet autoimmunity, often many years before clinical symptoms arise. While T cells play a major role in the destruction of pancreatic beta cells, molecular underpinnings promoting aberrant T cell activation remain poorly understood. Here, we show that during islet aut...
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Full title
miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes
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TN_cdi_doaj_primary_oai_doaj_org_article_224be2193f454379b9efe6527272f625
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_224be2193f454379b9efe6527272f625
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13587-3
