Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma
Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma
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Author / Creator
Dimitrakopoulos, Christos , Hindupur, Sravanth Kumar , Colombi, Marco , Liko, Dritan , Ng, Charlotte K. Y. , Piscuoglio, Salvatore , Behr, Jonas , Moore, Ariane L. , Singer, Jochen , Ruscheweyh, Hans-Joachim , Matter, Matthias S. , Mossmann, Dirk , Terracciano, Luigi M. , Hall, Michael N. and Beerenwinkel, Niko
Publisher
London: BioMed Central Ltd
Journal title
Language
English
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Publisher
London: BioMed Central Ltd
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Contents
Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly understood. Here, we explored the effect of defined genetic changes on the transcriptome, proteome and phosphoproteome in twelve tumors from an mTOR-driven hepatocellular carcinoma mouse model. Using Network-based...
Alternative Titles
Full title
Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_224fb61594c44244800fcd87efa2b40b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_224fb61594c44244800fcd87efa2b40b
Other Identifiers
ISSN
1471-2164
E-ISSN
1471-2164
DOI
10.1186/s12864-021-07876-9
