Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Alternative cleavage and polyadenylation (APA), an RNA processing event, occurs in over 70% of human protein-coding genes. APA results in mRNA transcripts with distinct 3' ends. Most APA occurs within 3' UTRs, which harbor regulatory elements that can impact mRNA stability, translation, and localization.
APA can be profiled using a number of est...
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Full title
Benchmarking sequencing methods and tools that facilitate the study of alternative polyadenylation
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TN_cdi_doaj_primary_oai_doaj_org_article_22c00d4c07e64f17a1f66809b2181167
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_22c00d4c07e64f17a1f66809b2181167
Other Identifiers
ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02502-z
