Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling
Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling
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United States: American Society for Clinical Investigation
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Language
English
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United States: American Society for Clinical Investigation
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Insulin and IGF-1 receptors (IR and IGF1R) are highly homologous and share similar signaling systems, but each has a unique physiological role, with IR primarily regulating metabolic homeostasis and IGF1R regulating mitogenic control and growth. Here, we show that replacement of a single amino acid at position 973, just distal to the NPEY motif in...
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Full title
Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling
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TN_cdi_doaj_primary_oai_doaj_org_article_22ea319743b447ccb3e07487b07381ad
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_22ea319743b447ccb3e07487b07381ad
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ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI161472
