Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Telomerase is a specialized reverse transcriptase that adds GGTTAG repeats to chromosome ends and is upregulated in most human cancers to enable limitless proliferation. Here, we uncover two distinct mechanisms by which naturally occurring oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elongation. We conduct a series of d...
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Mechanisms of telomerase inhibition by oxidized and therapeutic dNTPs
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TN_cdi_doaj_primary_oai_doaj_org_article_22fa7349443040f6a588333c1ddf1b4e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_22fa7349443040f6a588333c1ddf1b4e
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19115-y
