New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-prolif...
New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
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Publisher
Abingdon: Taylor & Francis
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Language
English
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Publisher
Abingdon: Taylor & Francis
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Contents
New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds were estimated against A549, Caco-2, HepG2, and MDA-MB-231. Compounds 13 and 14 showed comparable activities with doxorubicin against the Caco-2 cells. These compounds strongly inhibited VEGFR-...
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Full title
New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies
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TN_cdi_doaj_primary_oai_doaj_org_article_23225f8a56d246569bcac354c3c67f09
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_23225f8a56d246569bcac354c3c67f09
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ISSN
1475-6366
E-ISSN
1475-6374
DOI
10.1080/14756366.2022.2110869
