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Underground isoleucine biosynthesis pathways in E. coli

Underground isoleucine biosynthesis pathways in E. coli

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_235537e1aaab4346aaee0e7963eb12d8

Underground isoleucine biosynthesis pathways in E. coli

About this item

Full title

Underground isoleucine biosynthesis pathways in E. coli

Publisher

England: eLife Science Publications, Ltd

Journal title

eLife, 2020-08, Vol.9

Language

English

Formats

Publication information

Publisher

England: eLife Science Publications, Ltd

More information

Scope and Contents

Contents

The promiscuous activities of enzymes provide fertile ground for the evolution of new metabolic pathways. Here, we systematically explore the ability of
E. coli
to harness underground metabolism to compensate for the deletion of an essential biosynthetic pathway. By deleting all threonine deaminases, we generated a strain in which isoleucine...

Alternative Titles

Full title

Underground isoleucine biosynthesis pathways in E. coli

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_235537e1aaab4346aaee0e7963eb12d8

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_235537e1aaab4346aaee0e7963eb12d8

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.54207

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