Underground isoleucine biosynthesis pathways in E. coli
Underground isoleucine biosynthesis pathways in E. coli
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Publisher
England: eLife Science Publications, Ltd
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Language
English
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Publisher
England: eLife Science Publications, Ltd
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Contents
The promiscuous activities of enzymes provide fertile ground for the evolution of new metabolic pathways. Here, we systematically explore the ability of
E. coli
to harness underground metabolism to compensate for the deletion of an essential biosynthetic pathway. By deleting all threonine deaminases, we generated a strain in which isoleucine...
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Full title
Underground isoleucine biosynthesis pathways in E. coli
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TN_cdi_doaj_primary_oai_doaj_org_article_235537e1aaab4346aaee0e7963eb12d8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_235537e1aaab4346aaee0e7963eb12d8
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.54207