Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
About this item
Full title
Author / Creator
Sergin, Ismail , Evans, Trent D. , Zhang, Xiangyu , Bhattacharya, Somashubhra , Stokes, Carl J. , Song, Eric , Ali, Sahl , Dehestani, Babak , Holloway, Karyn B. , Micevych, Paul S. , Javaheri, Ali , Crowley, Jan R. , Ballabio, Andrea , Schilling, Joel D. , Epelman, Slava , Weihl, Conrad C. , Diwan, Abhinav , Fan, Daping , Zayed, Mohamed A. and Razani, Babak
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and organelles. Here we show that a decline in the autophagy–lysosome system contributes to this as evidenc...
Alternative Titles
Full title
Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis
Authors, Artists and Contributors
Author / Creator
Evans, Trent D.
Zhang, Xiangyu
Bhattacharya, Somashubhra
Stokes, Carl J.
Song, Eric
Ali, Sahl
Dehestani, Babak
Holloway, Karyn B.
Micevych, Paul S.
Javaheri, Ali
Crowley, Jan R.
Ballabio, Andrea
Schilling, Joel D.
Epelman, Slava
Weihl, Conrad C.
Diwan, Abhinav
Fan, Daping
Zayed, Mohamed A.
Razani, Babak
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2386c202410647229c348496bc117d5b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2386c202410647229c348496bc117d5b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15750
