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A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibili...

A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibili...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2391b8bc3f054907a3cb1f656085705b

A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population

About this item

Full title

A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population

Publisher

England: BioMed Central Ltd

Journal title

European journal of medical research, 2025-05, Vol.30 (1), p.421-11, Article 421

Language

English

Formats

Publication information

Publisher

England: BioMed Central Ltd

More information

Scope and Contents

Contents

A pathogenetic factor of ischemic stroke (IS) is oxidative stress. As a rate-limiting enzyme constituent in the glutathione synthetic pathway, the glutamate-cysteine ligase catalytic subunit (GCLC) exerts a crucial effect on the redox homeostasis. Several studies have shown that variants of the GCLC gene are related to susceptibility to various dis...

Alternative Titles

Full title

A genetic variant of the glutamate-cysteine ligase catalytic subunit is associated with susceptibility to ischemic stroke in the Chinese population

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_2391b8bc3f054907a3cb1f656085705b

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2391b8bc3f054907a3cb1f656085705b

Other Identifiers

ISSN

2047-783X,0949-2321

E-ISSN

2047-783X

DOI

10.1186/s40001-025-02688-z

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