An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin sign...
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis
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Author / Creator
Ainscough, Alexander J. , Smith, Timothy J. , Haensel, Maike , Rhodes, Christopher J. , Fellows, Adam , Whitwell, Harry J. , Vasilaki, Eleni , Gray, Kelly , Freeman, Adrian , Howard, Luke S. , Wharton, John , Dunmore, Benjamin , Upton, Paul D. , Wilkins, Martin R. , Edel, Joshua B. and Wojciak-Stothard, Beata
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Pulmonary arterial hypertension (PAH) is an unmet clinical need. The lack of models of human disease is a key obstacle to drug development. We present a biomimetic model of pulmonary arterial endothelial-smooth muscle cell interactions in PAH, combining natural and induced bone morphogenetic protein receptor 2 (BMPR2) dysfunction with hypoxia to in...
Alternative Titles
Full title
An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_23b65781f0864f158a058def624a88d9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_23b65781f0864f158a058def624a88d9
Other Identifiers
ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-022-04169-z
