RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery
RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Formalin-fixed, paraffin-embedded (FFPE) tissues for RNA-seq have advantages over fresh frozen tissue including abundance and availability, connection to rich clinical data, and association with patient outcomes. However, FFPE-derived RNA is highly degraded and chemically modified, which impacts its utility as a faithful source for biological inqui...
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RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery
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TN_cdi_doaj_primary_oai_doaj_org_article_23cdb8883d2b4c058fc474177b85152b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_23cdb8883d2b4c058fc474177b85152b
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ISSN
1755-8794
E-ISSN
1755-8794
DOI
10.1186/s12920-019-0643-z
