Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY330005...
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054
About this item
Full title
Author / Creator
Li, Yiwen , Carpenito, Carmine , Wang, George , Surguladze, David , Forest, Amelie , Malabunga, Maria , Murphy, Mary , Zhang, Yiwei , Sonyi, Andreas , Chin, Darin , Burtrum, Douglas , Inigo, Ivan , Pennello, Anthony , Shen, Leyi , Malherbe, Laurent , Chen, Xinlei , Hall, Gerald , Haidar, Jaafar N. , Ludwig, Dale L. , Novosiadly, Ruslan D. and Kalos, Michael
Publisher
England: BioMed Central Ltd
Journal title
Language
English
Formats
Publication information
Publisher
England: BioMed Central Ltd
Subjects
More information
Scope and Contents
Contents
Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable objective responses in a subset of patients across multiple tumor types.
Here we describe the discovery and preclinic...
Alternative Titles
Full title
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054
Authors, Artists and Contributors
Author / Creator
Carpenito, Carmine
Wang, George
Surguladze, David
Forest, Amelie
Malabunga, Maria
Murphy, Mary
Zhang, Yiwei
Sonyi, Andreas
Chin, Darin
Burtrum, Douglas
Inigo, Ivan
Pennello, Anthony
Shen, Leyi
Malherbe, Laurent
Chen, Xinlei
Hall, Gerald
Haidar, Jaafar N.
Ludwig, Dale L.
Novosiadly, Ruslan D.
Kalos, Michael
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_23eb068b1c80433fb11267b151e41edf
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_23eb068b1c80433fb11267b151e41edf
Other Identifiers
ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1186/s40425-018-0329-7
