Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle tempora...
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
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Author / Creator
Chen, Shuo , Chang, Yuzhou , Li, Liangping , Acosta, Diana , Li, Yang , Guo, Qi , Wang, Cankun , Turkes, Emir , Morrison, Cody , Julian, Dominic , Hester, Mark E , Scharre, Douglas W , Santiskulvong, Chintda , Song, Sarah XueYing , Plummer, Jasmine T , Serrano, Geidy E , Beach, Thomas G , Duff, Karen E , Ma, Qin and Fu, Hongjun
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's disease (AD), but little is known about the molecular mechanisms underlying this regional vulnerability. Here we utilize the 10 × Visium platform to define the spatial transcriptomic profile in both AD and control (CT) MTG. We identify unique marker genes for cortic...
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Full title
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
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TN_cdi_doaj_primary_oai_doaj_org_article_2440d9d04a75482092b0985a2c1cb523
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2440d9d04a75482092b0985a2c1cb523
Other Identifiers
ISSN
2051-5960
E-ISSN
2051-5960
DOI
10.1186/s40478-022-01494-6
