The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reti...
The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Upon endoplasmic-reticulum (ER) stress, the ER-located transmembrane protein, Ire1, is autophosphorylated and acts as an endoribonuclease to trigger the unfolded protein response (UPR). Previous biochemical studies have shown that Ire1 exhibits strong endoribonuclease activity when its cytosolic kinase region captures ADP. Here, we asked how this e...
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The ADP-binding kinase region of Ire1 directly contributes to its responsiveness to endoplasmic reticulum stress
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TN_cdi_doaj_primary_oai_doaj_org_article_244f0bfeceb04e76b0aedb99335c2c9a
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_244f0bfeceb04e76b0aedb99335c2c9a
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-021-83890-x
