Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1
Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1
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He, Qinglian , Ye, Aihua , Ye, Weibiao , Liao, Xiaomin , Qin, Guoqiang , Xu, Yongqiang , Yin, Yuting , Luo, Huanqian , Yi, Muhua , Xian, Liying , Zhang, Shihao , Qin, Xiyuan , Zhu, Wei and Li, Yuling
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Cancer-secreted exosomes are critical mediators of cancer-host crosstalk. In the present study, we showed the delivery of miR-21-5p from colorectal cancer (CRC) cells to endothelial cells via exosomes increased the amount of miR-21-5p in recipient cells. MiR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequ...
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Full title
Cancer-secreted exosomal miR-21-5p induces angiogenesis and vascular permeability by targeting KRIT1
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TN_cdi_doaj_primary_oai_doaj_org_article_2453b2bff10f447aa9beec21381307fb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2453b2bff10f447aa9beec21381307fb
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-021-03803-8
