Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabi...
Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
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Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL) , Neuberger, Arthur , Trofimov, Yury A. , Yelshanskaya, Maria V. , Khau, Jeffrey , Nadezhdin, Kirill D. , Khosrof, Lena S. , Krylov, Nikolay A. , Efremov, Roman G. and Sobolevsky, Alexander I.
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The calcium-selective oncochannel TRPV6 is an important driver of cell proliferation in human cancers. Despite increasing interest of pharmacological research in developing synthetic inhibitors of TRPV6, natural compounds acting at this channel have been largely neglected. On the other hand, pharmacokinetics of natural small-molecule antagonists op...
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Molecular pathway and structural mechanism of human oncochannel TRPV6 inhibition by the phytocannabinoid tetrahydrocannabivarin
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TN_cdi_doaj_primary_oai_doaj_org_article_24770a8288e94d4a9af6eb8f2702c528
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_24770a8288e94d4a9af6eb8f2702c528
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40362-2
