Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing
Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Bloom syndrome (BS) is associated with a profoundly increased cancer risk and is caused by mutations in the Bloom helicase (BLM). BLM is involved in the nucleolytic processing of the ends of DNA double–strand breaks (DSBs), to yield long 3′ ssDNA tails that serve as the substrate for break repair by homologous recombination (HR). Here, we use singl...
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Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing
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TN_cdi_doaj_primary_oai_doaj_org_article_249006cafba94dcf911c7aad8b796856
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_249006cafba94dcf911c7aad8b796856
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-29937-7
