944 Obese, not starving: mitochondrial citrate export drives lipid accumulation and dysfunction in e...
944 Obese, not starving: mitochondrial citrate export drives lipid accumulation and dysfunction in exhausted T cells
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London: BMJ Publishing Group Ltd
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English
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London: BMJ Publishing Group Ltd
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BackgroundThe efficacy of immunotherapy depends on the presence and persistence of functional immune cells within the tumor. While tumor-specific T cells can be activated and infiltrate the tumor microenvironment, they are quickly rendered dysfunctional by the combination of chronic antigen stimulation and metabolic stress, resulting in an altered...
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944 Obese, not starving: mitochondrial citrate export drives lipid accumulation and dysfunction in exhausted T cells
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TN_cdi_doaj_primary_oai_doaj_org_article_24c087ad1403421b971c5f3e02af7c18
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_24c087ad1403421b971c5f3e02af7c18
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E-ISSN
2051-1426
DOI
10.1136/jitc-2023-SITC2023.0944
