rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heter...
rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
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Yu, Hua , Sun, Zhen , Tan, Tianyu , Pan, Hongru , Zhao, Jing , Zhang, Ling , Chen, Jiayu , Lei, Anhua , Zhu, Yuqing , Chen, Lang , Xu, Yuyan , Liu, Yaxin , Chen, Ming , Sheng, Jinghao , Xu, Zhengping , Qian, Pengxu , Li, Cheng , Gao, Shaorong , Daley, George Q. and Zhang, Jin
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The nucleolus is the organelle for ribosome biogenesis and sensing various types of stress. However, its role in regulating stem cell fate remains unclear. Here, we present evidence that nucleolar stress induced by interfering rRNA biogenesis can drive the 2-cell stage embryo-like (2C-like) program and induce an expanded 2C-like cell population in...
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rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
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TN_cdi_doaj_primary_oai_doaj_org_article_24ed821a05d7423a843829e3bb8e0f2c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_24ed821a05d7423a843829e3bb8e0f2c
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-26576-2
