High tumor mutational burden assessed through next-generation sequencing predicts favorable survival...
High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients
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Author / Creator
Di Mauro, Annabella , Santorsola, Mariachiara , Savarese, Giovanni , Sirica, Roberto , Ianniello, Monica , Cossu, Alessia Maria , Ceccarelli, Anna , Sabbatino, Francesco , Bocchetti, Marco , Carratù, Anna Chiara , Pentimalli, Francesca , Ferrara, Gerardo , Nasti, Guglielmo , Caraglia, Michele and Ottaiano, Alessandro
Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Microsatellite instability (MSI) is a well-established predictive biomarker for immune checkpoint inhibitor (ICI) response in metastatic colon cancer. Both high MSI and tumor mutational burden (TMB) are markers of genomic instability. However, the prognostic and predictive value of TMB in patients with microsatellite stable (MSS) tumors remains unc...
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Full title
High tumor mutational burden assessed through next-generation sequencing predicts favorable survival in microsatellite stable metastatic colon cancer patients
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TN_cdi_doaj_primary_oai_doaj_org_article_2511af399ba9499ab479b1e841ab980d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2511af399ba9499ab479b1e841ab980d
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ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-024-05927-9
