Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Function...
Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine
About this item
Full title
Author / Creator
Weber, Patrick , Thonhofer, Martin , Averill, Summer , Davies, Gideon J , Santana, Andres Gonzalez , Müller, Philipp , Nasseri, Seyed A , Offen, Wendy A , Pabst, Bettina M , Paschke, Eduard , Schalli, Michael , Torvisco, Ana , Tschernutter, Marion , Tysoe, Christina , Windischhofer, Werner , Withers, Stephen G , Wolfsgruber, Andreas , Wrodnigg, Tanja M and Stütz, Arnold E
Publisher
Switzerland: MDPI AG
Journal title
Language
English
Formats
Publication information
Publisher
Switzerland: MDPI AG
Subjects
More information
Scope and Contents
Contents
Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaperoning activities determined and compared with those of lipophilic analogs of the potent β-d-galactosi...
Alternative Titles
Full title
Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C -5a-Substituted Derivatives of 4- epi -Isofagomine
Authors, Artists and Contributors
Author / Creator
Thonhofer, Martin
Averill, Summer
Davies, Gideon J
Santana, Andres Gonzalez
Müller, Philipp
Nasseri, Seyed A
Offen, Wendy A
Pabst, Bettina M
Paschke, Eduard
Schalli, Michael
Torvisco, Ana
Tschernutter, Marion
Tysoe, Christina
Windischhofer, Werner
Withers, Stephen G
Wolfsgruber, Andreas
Wrodnigg, Tanja M
Stütz, Arnold E
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_25403e0b400e40b799edabad23624a55
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_25403e0b400e40b799edabad23624a55
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules25174025
