Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation...
Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs
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London: BioMed Central Ltd
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English
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London: BioMed Central Ltd
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Background Fibroblast growth factor receptor (FGFR) gene family alterations are found in several cancers, indicating their importance as potential therapeutic targets. The FGFR-tyrosine kinase inhibitor (TKI) pemigatinib has been introduced in the treatment of advanced cholangiocarcinoma and more recently for relapsed or refractory myeloid/lymphoid...
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Targeting FGFRs by pemigatinib induces G1 phase cell cycle arrest, cellular stress and upregulation of tumor suppressor microRNAs
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TN_cdi_doaj_primary_oai_doaj_org_article_255236c69f6b466e83fed56613c8381c
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_255236c69f6b466e83fed56613c8381c
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ISSN
1479-5876
E-ISSN
1479-5876
DOI
10.1186/s12967-023-04450-7
