HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance
HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Vinca alkaloids, a class of tubulin-binding agent, are widely used in treating cancer, yet the emerging resistance compromises their efficacy. Hepatoma up-regulated protein (HURP), a microtubule-associated protein displaying heightened expression across various cancer types, reduces cancer cells’ sensitivity to vinca-alkaloid drugs upon overexpress...
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HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance
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TN_cdi_doaj_primary_oai_doaj_org_article_25c9cd49c7d1431aa1ea38ff3a4d9bb6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_25c9cd49c7d1431aa1ea38ff3a4d9bb6
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-53139-y
