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Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation o...

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation o...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_25d31a933533497b92cc285f9433ec89

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein

About this item

Full title

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein

Publisher

United States: Public Library of Science

Journal title

PLoS pathogens, 2024-12, Vol.20 (12), p.e1012715

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Several Old World and New World
Mammarenavirus
are responsible for hemorrhagic fever in humans. These enveloped viruses have a bi-segmented ambisense RNA genome that encodes four proteins. All
Mammarenavirus
identified to date share a common dependency on myristoylation: the addition of the C14 myristic acid on the N-terminal G2 residue...

Alternative Titles

Full title

Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_25d31a933533497b92cc285f9433ec89

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_25d31a933533497b92cc285f9433ec89

Other Identifiers

ISSN

1553-7374,1553-7366

E-ISSN

1553-7374

DOI

10.1371/journal.ppat.1012715

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