Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC
Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
KdpFABC, a high-affinity K
+
pump, combines the ion channel KdpA and the P-type ATPase KdpB to secure survival at K
+
limitation. Here, we apply a combination of cryo-EM, biochemical assays, and MD simulations to illuminate the mechanisms underlying transport and the coupling to ATP hydrolysis. We show that ions are transported via an i...
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Full title
Deciphering ion transport and ATPase coupling in the intersubunit tunnel of KdpFABC
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TN_cdi_doaj_primary_oai_doaj_org_article_2620f43c74cb4b05a260da650d8ad4ff
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2620f43c74cb4b05a260da650d8ad4ff
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25242-x
