SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration a...
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
About this item
Full title
Author / Creator
Hautbergue, Guillaume M. , Castelli, Lydia M. , Ferraiuolo, Laura , Sanchez-Martinez, Alvaro , Cooper-Knock, Johnathan , Higginbottom, Adrian , Lin, Ya-Hui , Bauer, Claudia S. , Dodd, Jennifer E. , Myszczynska, Monika A. , Alam, Sarah M. , Garneret, Pierre , Chandran, Jayanth S. , Karyka, Evangelia , Stopford, Matthew J. , Smith, Emma F. , Kirby, Janine , Meyer, Kathrin , Kaspar, Brian K. , Isaacs, Adrian M. , El-Khamisy, Sherif F. , De Vos, Kurt J. , Ning, Ke , Azzouz, Mimoun , Whitworth, Alexander J. and Shaw, Pamela J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Hexanucleotide repeat expansions in the
C9ORF72
gene are the commonest known genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Expression of repeat transcripts and dipeptide repeat proteins trigger multiple mechanisms of neurotoxicity. How repeat transcripts get exported from the nucleus is unknown. Here, we show tha...
Alternative Titles
Full title
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits
Authors, Artists and Contributors
Author / Creator
Castelli, Lydia M.
Ferraiuolo, Laura
Sanchez-Martinez, Alvaro
Cooper-Knock, Johnathan
Higginbottom, Adrian
Lin, Ya-Hui
Bauer, Claudia S.
Dodd, Jennifer E.
Myszczynska, Monika A.
Alam, Sarah M.
Garneret, Pierre
Chandran, Jayanth S.
Karyka, Evangelia
Stopford, Matthew J.
Smith, Emma F.
Kirby, Janine
Meyer, Kathrin
Kaspar, Brian K.
Isaacs, Adrian M.
El-Khamisy, Sherif F.
De Vos, Kurt J.
Ning, Ke
Azzouz, Mimoun
Whitworth, Alexander J.
Shaw, Pamela J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_26d01605fb7344faaa67f88fe2c80e8f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_26d01605fb7344faaa67f88fe2c80e8f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms16063
