In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evo...
In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Locus coeruleus (LC) neurons in the brainstem have long been associated with attention and arousal. Optogenetic stimulation of LC-NE neurons induces immediate sleep-to-wake transitions. However, LC neurons also secrete other neurotransmitters in addition to NE. To interrogate the role of NE derived from the LC in regulating wakefulness, we applied...
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In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness
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TN_cdi_doaj_primary_oai_doaj_org_article_26d3ded6f2ac42a3a93af43e8748351e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_26d3ded6f2ac42a3a93af43e8748351e
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2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07566-3
