HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
About this item
Full title
Author / Creator
Yan, TingDong , Ooi, Wen Fong , Qamra, Aditi , Cheung, Alice , Ma, DongLiang , Sundaram, Gopinath Meenakshi , Xu, Chang , Xing, Manjie , Poon, LaiFong , Wang, Jing , Loh, Yan Ping , Ho, Jess Hui Jie , Ng, Joscelyn Jun Quan , Ramlee, Muhammad Khairul , Aswad, Luay , Rozen, Steve G. , Ghosh, Sujoy , Bard, Frederic A. , Sampath, Prabha , Tergaonkar, Vinay , Davies, James O. J. , Hughes, Jim R. , Goh, Eyleen , Bi, Xuezhi , Fullwood, Melissa Jane , Tan, Patrick and Li, Shang
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses
hTERT
expression.
mir
-
615
-
3...
Alternative Titles
Full title
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
Authors, Artists and Contributors
Author / Creator
Ooi, Wen Fong
Qamra, Aditi
Cheung, Alice
Ma, DongLiang
Sundaram, Gopinath Meenakshi
Xu, Chang
Xing, Manjie
Poon, LaiFong
Wang, Jing
Loh, Yan Ping
Ho, Jess Hui Jie
Ng, Joscelyn Jun Quan
Ramlee, Muhammad Khairul
Aswad, Luay
Rozen, Steve G.
Ghosh, Sujoy
Bard, Frederic A.
Sampath, Prabha
Tergaonkar, Vinay
Davies, James O. J.
Hughes, Jim R.
Goh, Eyleen
Bi, Xuezhi
Fullwood, Melissa Jane
Tan, Patrick
Li, Shang
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_277e679dd3d749c1b6f4ca18ea150063
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_277e679dd3d749c1b6f4ca18ea150063
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02601-1
