NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription...
NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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The molecular basis underlying glioblastoma (GBM) heterogeneity and plasticity is not fully understood. Using transcriptomic data of human patient-derived brain tumor stem cell lines (BTSCs), classified based on GBM-intrinsic signatures, we identify the AP-1 transcription factor
as a key regulator of the mesenchymal (MES) subtype. We provide a m...
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Full title
NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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TN_cdi_doaj_primary_oai_doaj_org_article_27a8334b7595495aa16d1f8e55366e1e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_27a8334b7595495aa16d1f8e55366e1e
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.64846
