A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibiti...
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
About this item
Full title
Author / Creator
Mahoney, Christopher E. , Pirman, David , Chubukov, Victor , Sleger, Taryn , Hayes, Sebastian , Fan, Zi Peng , Allen, Eric L. , Chen, Ying , Huang, Lingling , Liu, Meina , Zhang, Yingjia , McDonald, Gabrielle , Narayanaswamy, Rohini , Choe, Sung , Chen, Yue , Gross, Stefan , Cianchetta, Giovanni , Padyana, Anil K. , Murray, Stuart , Liu, Wei , Marks, Kevin M. , Murtie, Joshua , Dorsch, Marion , Jin, Shengfang , Nagaraja, Nelamangala , Biller, Scott A. , Roddy, Thomas , Popovici-Muller, Janeta and Smolen, Gromoslaw A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the cholesterol biosynthetic pathway enzy...
Alternative Titles
Full title
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
Authors, Artists and Contributors
Author / Creator
Pirman, David
Chubukov, Victor
Sleger, Taryn
Hayes, Sebastian
Fan, Zi Peng
Allen, Eric L.
Chen, Ying
Huang, Lingling
Liu, Meina
Zhang, Yingjia
McDonald, Gabrielle
Narayanaswamy, Rohini
Choe, Sung
Chen, Yue
Gross, Stefan
Cianchetta, Giovanni
Padyana, Anil K.
Murray, Stuart
Liu, Wei
Marks, Kevin M.
Murtie, Joshua
Dorsch, Marion
Jin, Shengfang
Nagaraja, Nelamangala
Biller, Scott A.
Roddy, Thomas
Popovici-Muller, Janeta
Smolen, Gromoslaw A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_27aeab8f4bce40e788924435c21f0b77
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_27aeab8f4bce40e788924435c21f0b77
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-07959-4
