Lysosomal recruitment of TSC2 is a universal response to cellular stress
Lysosomal recruitment of TSC2 is a universal response to cellular stress
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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mTORC1 promotes cell growth and is therefore inactivated upon unfavourable growth conditions. Signalling pathways downstream of most cellular stresses converge on TSC1/2, which serves as an integration point that inhibits mTORC1. The TSC1/2 complex was shown to translocate to lysosomes to inactivate mTORC1 in response to two stresses: amino-acid st...
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Lysosomal recruitment of TSC2 is a universal response to cellular stress
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TN_cdi_doaj_primary_oai_doaj_org_article_27c04ce164a1440f867e94660882754d
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_27c04ce164a1440f867e94660882754d
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms10662
