IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
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Author / Creator
Tian, Miao , Wang, Xiumei , Sun, Jihong , Lin, Wenlong , Chen, Lumin , Liu, Shengduo , Wu, Ximei , Shi, Liyun , Xu, Pinglong , Cai, Xiujun and Wang, Xiaojian
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Occurrence of Colorectal cancer (CRC) is relevant with gut microbiota. However, role of IRF3, a key signaling mediator in innate immune sensing, has been barely investigated in CRC. Here, we unexpectedly found that the IRF3 deficient mice are hyper-susceptible to the development of intestinal tumor in AOM/DSS and Apc
min/+
models. Genetic abl...
Alternative Titles
Full title
IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin
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TN_cdi_doaj_primary_oai_doaj_org_article_27fd64e8f5954df280d638580267b400
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_27fd64e8f5954df280d638580267b400
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-19627-7
