Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lun...
Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
About this item
Full title
Author / Creator
Wang, Rong , Yamada, Tadaaki , Kita, Kenji , Taniguchi, Hirokazu , Arai, Sachiko , Fukuda, Koji , Terashima, Minoru , Ishimura, Akihiko , Nishiyama, Akihiro , Tanimoto, Azusa , Takeuchi, Shinji , Ohtsubo, Koshiro , Yamashita, Kaname , Yamano, Tomoyoshi , Yoshimura, Akihiro , Takayama, Koichi , Kaira, Kyoichi , Taniguchi, Yoshihiko , Atagi, Shinji , Uehara, Hisanori , Hanayama, Rikinari , Matsumoto, Isao , Han, Xujun , Matsumoto, Kunio , Wang, Wei , Suzuki, Takeshi and Yano, Seiji
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Drug tolerance is the basis for acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) including osimertinib, through mechanisms that still remain unclear. Here, we show that while AXL-low expressing
EGFR
mutated lung cancer (
EGFR
mut-LC) cells are more sensitive to osimertinib than AXL-high expr...
Alternative Titles
Full title
Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer
Authors, Artists and Contributors
Author / Creator
Yamada, Tadaaki
Kita, Kenji
Taniguchi, Hirokazu
Arai, Sachiko
Fukuda, Koji
Terashima, Minoru
Ishimura, Akihiko
Nishiyama, Akihiro
Tanimoto, Azusa
Takeuchi, Shinji
Ohtsubo, Koshiro
Yamashita, Kaname
Yamano, Tomoyoshi
Yoshimura, Akihiro
Takayama, Koichi
Kaira, Kyoichi
Taniguchi, Yoshihiko
Atagi, Shinji
Uehara, Hisanori
Hanayama, Rikinari
Matsumoto, Isao
Han, Xujun
Matsumoto, Kunio
Wang, Wei
Suzuki, Takeshi
Yano, Seiji
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_286176aadbbc411dbfd32550becc33c5
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_286176aadbbc411dbfd32550becc33c5
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18442-4
