An EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumor...
An EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumors in cancer patients
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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We previously introduced a random-effects model to analyze a set of patients, each of which has two distinct tumors. The goal is to estimate the proportion of patients for which one of the tumors is a metastasis of the other, i.e. where the tumors are clonally related. Matches of mutations within a tumor pair provide the evidence for clonal related...
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Full title
An EM algorithm to improve the estimation of the probability of clonal relatedness of pairs of tumors in cancer patients
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TN_cdi_doaj_primary_oai_doaj_org_article_28636b07808e425089dd12c9228c0c8b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_28636b07808e425089dd12c9228c0c8b
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ISSN
1471-2105
E-ISSN
1471-2105
DOI
10.1186/s12859-019-3148-z
