NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism
NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism
About this item
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Author / Creator
Liu, Jiao , Tang, Hu , Chen, Fangquan , Li, Changfeng , Xie, Yangchun , Kang, Rui and Tang, Daolin
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Cuproptosis is a recently discovered form of regulated cell death triggered by mitochondrial copper accumulation and proteotoxic stress. Here, we provide the first evidence that glutathione (GSH), a major non-protein thiol in cells, acts as a cuproptosis inhibitor in pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, GSH inhibits cupro...
Alternative Titles
Full title
NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_288a89af25a0440aa550cc02ba2f3f8b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_288a89af25a0440aa550cc02ba2f3f8b
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-024-81317-x
