CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-speci...
CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies
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Publisher
England: BioMed Central Ltd
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Language
English
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Publisher
England: BioMed Central Ltd
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Contents
Genes contain multiple promoters that can drive the expression of various transcript isoforms. Although transcript isoforms from the same gene could have diverse and non-overlapping functions, current loss-of-function methodologies are not able to differentiate between isoform-specific phenotypes.
Here, we show that CRISPR interference (CRISPRi)...
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CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies
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TN_cdi_doaj_primary_oai_doaj_org_article_28a92aa18b2c4969997ffae4ef54a6a9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_28a92aa18b2c4969997ffae4ef54a6a9
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ISSN
1474-760X,1474-7596
E-ISSN
1474-760X
DOI
10.1186/s13059-021-02266-6
