A protein domain interaction interface database: InterPare
A protein domain interaction interface database: InterPare
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Most proteins function by interacting with other molecules. Their interaction interfaces are highly conserved throughout evolution to avoid undesirable interactions that lead to fatal disorders in cells. Rational drug discovery includes computational methods to identify the interaction sites of lead compounds to the target molecules. Identifying and classifying protein interaction interfaces on a large scale can help researchers discover drug targets more efficiently.
We introduce a large-scale protein domain interaction interface database called InterPare http://interpare.net. It contains both inter-chain (between chains) interfaces and intra-chain (within chain) interfaces. InterPare uses three methods to detect interfaces: 1) the geometric distance method for checking the distance between atoms that belong to different domains, 2) Accessible Surface Area (ASA), a method for detecting the buried region of a protei...
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A protein domain interaction interface database: InterPare
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TN_cdi_doaj_primary_oai_doaj_org_article_28c52dac2b50407db800da3d0b09fc5b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_28c52dac2b50407db800da3d0b09fc5b
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ISSN
1471-2105
E-ISSN
1471-2105
DOI
10.1186/1471-2105-6-207
