Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmissi...
Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen
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Author / Creator
Bender, Nicole G. , Khare, Prachi , Martinez, Juan , Tweedell, Rebecca E. , Nyasembe, Vincent O. , López-Gutiérrez, Borja , Tripathi, Abhai , Miller, Dustin , Hamerly, Timothy , Vela, Eric M. , Davis, Ryan R. , Howard, Randall F. , Nsango, Sandrine , Cobb, Ronald R. , Harbers, Matthias and Dinglasan, Rhoel R.
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Malaria transmission-blocking vaccines (TBVs) prevent the completion of the developmental lifecycle of malarial parasites within the mosquito vector, effectively blocking subsequent infections. The mosquito midgut protein Anopheline alanyl aminopeptidase N (AnAPN1) is the leading, mosquito-based TBV antigen. Structure-function studies identified tw...
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Full title
Immunofocusing humoral immunity potentiates the functional efficacy of the AnAPN1 malaria transmission-blocking vaccine antigen
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TN_cdi_doaj_primary_oai_doaj_org_article_28e79b6e90d24744bdea15515a7a039e
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_28e79b6e90d24744bdea15515a7a039e
Other Identifiers
ISSN
2059-0105
E-ISSN
2059-0105
DOI
10.1038/s41541-021-00309-4
